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Parasite genetics, genomics and proteomics

Subject Editor
Xing-Quan Zhu, Shanxi Agricultural University, China

Associate Editors
Jenny Maloney, PhD, United States Department of Agriculture, Agricultural Research Service, USA

Seth Redmond, Queen Mary University of London, UK

Javier Sotillo-Gallego, National Centre for Microbiology, Spain
 

The Parasite genetics, genomics and proteomics section publishes studies applying platform technologies to the innovation of diagnostics, therapeutics and vaccines for parasitic diseases.

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  1. Anaplasma phagocytophilum is a tick-vectored, obligately intracellular bacterium that infects a diversity of vertebrate hosts. In North America, the Ap-ha variant of A. phagocytophilum can cause dangerous infecti...

    Authors: Matthew L. Aardema
    Citation: Parasites & Vectors 2023 16:301
  2. Components of the antioxidant defense system in Trypanosoma cruzi are potential targets for new drug development. Superoxide dismutases (SODs) constitute key components of antioxidant defense systems, removing ex...

    Authors: Jéssica Hickson, Lucas Felipe Almeida Athayde, Thainá Godinho Miranda, Policarpo Ademar Sales Junior, Anderson Coqueiro dos Santos, Lúcia Maria da Cunha Galvão, Antônia Cláudia Jácome da Câmara, Daniella Castanheira Bartholomeu, Rita de Cássia Moreira de Souza, Silvane Maria Fonseca Murta and Laila Alves Nahum
    Citation: Parasites & Vectors 2022 15:194
  3. Schistosomiasis, an acute and chronic parasitic disease, causes substantial morbidity and mortality in tropical and subtropical regions of the world. Iron is an essential constituent of numerous macromolecules...

    Authors: Fanyuan Zeng, Cun Yi, Wei Zhang, Shaoyun Cheng, Chengsong Sun, Fang Luo, Zheng Feng and Wei Hu
    Citation: Parasites & Vectors 2022 15:177
  4. Dengue is prevalent worldwide and is transmitted by Aedes mosquitoes. Temperature is a strong driver of dengue transmission. However, little is known about the underlying mechanisms.

    Authors: Zhuanzhuan Liu, Ye Xu, Yudi Li, Shihong Xu, Yiji Li, Ling Xiao, Xiaoguang Chen, Cheng He and Kuiyang Zheng
    Citation: Parasites & Vectors 2022 15:173
  5. Clonorchiasis, an infectious disease caused by the liver fluke Clonorchis sinensis, may lead to the development of liver and gallbladder diseases, and even cholangiocarcinoma (CCA). However, the pathogenesis, hos...

    Authors: Yang-Yuan Qiu, Qiao-Cheng Chang, Jun-Feng Gao, Ming-Jia Bao, Hai-Tao Luo, Jin-Ho Song, Sung-Jong Hong, Rui-Feng Mao, Yun-Yi Sun, Ying-Yu Chen, Ming-Yuan Liu, Chun-Ren Wang and Xiao-Lei Liu
    Citation: Parasites & Vectors 2022 15:172
  6. Ivermectin (IVM) is one of the most important and widely used anthelmintics in veterinary medicine. However, its efficacy is increasingly compromised by widespread resistance, and the exact mechanism of IVM re...

    Authors: Waresi Tuersong, Caixian Zhou, Simin Wu, Peixi Qin, Chunqun Wang, Wenda Di, Lu Liu, Hui Liu and Min Hu
    Citation: Parasites & Vectors 2022 15:159
  7. The nematode Parascaris univalens is one of the most prevalent parasitic pathogens infecting horses but anthelmintic resistance undermines treatment approaches. The molecular mechanisms underlying drug activity a...

    Authors: Faruk Dube, Andrea Hinas, Shweta Roy, Frida Martin, Magnus Åbrink, Staffan Svärd and Eva Tydén
    Citation: Parasites & Vectors 2022 15:158
  8. Primary infection of Toxoplasma gondii can cause serious abnormal pregnancy outcomes such as miscarriage and stillbirth. Inhibitory molecule B7-H4 is abundantly expressed in dendritic cells (DCs) and plays an imp...

    Authors: Xinyue Sun, Hongbing Xie, Haixia Zhang, Zhidan Li, Houbao Qi, Chunyan Yang, Xianbing Liu, Liqin Ren, Yuzhu Jiang and Xuemei Hu
    Citation: Parasites & Vectors 2022 15:157
  9. Animal African trypanosomiasis, or nagana, is a veterinary disease caused by African trypanosomes transmitted by tsetse flies. In Africa, Trypanosoma congolense is one of the most pathogenic and prevalent causes ...

    Authors: Sara Silva Pereira, Kawira Mathenge, Daniel Masiga and Andrew Jackson
    Citation: Parasites & Vectors 2022 15:152
  10. More than one-third of the total world population is infected by Toxoplasma gondii (T. gondii). T. gondii has been linked to various diseases, such as cancer, mental disorders, type 2 diabetes mellitus (T2DM), et...

    Authors: Kehui Zhu, Kun Liu, Junsi Huang, Xueqiong Weng, Qiaoyun Chen, Tianyu Gao, Kebing Chen, Chunxia Jing, Jing Wang and Guang Yang
    Citation: Parasites & Vectors 2022 15:151
  11. Diplozoidae are monogenean (Monogenea: Polyopisthocotylea) fish parasites characterised by a unique life history: two larvae permanently fuse into an X-shaped “Siamese” organism. Taxonomy and phylogeny of Dipl...

    Authors: Cui-Lan Hao, Kadirden Arken, Munira Kadir, Wen-Run Zhang, Meng-Jie Rong, Nian-Wen Wei, Yan-Jun Liu and Cheng Yue
    Citation: Parasites & Vectors 2022 15:149

    The Correction to this article has been published in Parasites & Vectors 2022 15:169

  12. We have reported the positive association of the cyclooxygenase 2 (COX-2)/prostaglandin E2 (PGE2) axis with liver fibrosis induced by Schistosoma japonicum (Sj) infection, and TLR4 signaling controlled this axis....

    Authors: Zhang Qi, Chen Lan, Ji Xiaofang, Tang Juanjuan, Fu Cheng, Huang Ting, Shen Erxia and Li Zi
    Citation: Parasites & Vectors 2022 15:144
  13. The olfactory system plays a crucial role in regulating insect behaviors. The detection of odorants is mainly mediated by various odorant receptors (ORs) that are expressed in the dendrites of olfactory neuron...

    Authors: Zhengbo He, Zhengrong Yu, Xingfei He, Youjin Hao, Liang Qiao, Shihui Luo, Jingjing Zhang and Bin Chen
    Citation: Parasites & Vectors 2022 15:143
  14. Microsporidia are a group of intracellular parasitic eukaryotes, serious pathogens that cause widespread infection in humans, vertebrates, and invertebrates. Because microsporidia have a thick spore wall struc...

    Authors: Zhanqi Dong, Na Gao, Boyuan Deng, Xuhua Huang, Congwu Hu, Peng Chen, Qin Wu, Cheng Lu and Minhui Pan
    Citation: Parasites & Vectors 2022 15:141
  15. The fast-declining clinical efficacy of dihydroartemisinin-piperaquine (DHA-PPQ) in Cambodia is a warning of the underlying westward dissemination of piperaquine resistance in the Greater Mekong Subregion (GMS...

    Authors: Run Ye, Yilong Zhang and Dongmei Zhang
    Citation: Parasites & Vectors 2022 15:130
  16. The genus Cissophyllus (Cosmocercoidea: Kathlaniidae) is a rare group of nematodes parasitic in turtles and lizards. To date, only four species have been reported in Asia and North America. However, most of them ...

    Authors: Xue-Feng Ni, Hui-Xia Chen, Zhen Xu, Xiao-Hong Gu and Liang Li
    Citation: Parasites & Vectors 2022 15:116
  17. Molecular markers are essential to identify Echinococcus species and genotypes in areas with multiple Echinococcus species to understand their epidemiology and pathology. Tibet Autonomous Region (TAR) is one of t...

    Authors: Yanping Zhao, Dunzhu Gesang, Li Wan, Jiandong Li, Gezhen Qiangba, Wangmu Danzeng, Zhuoga Basang, Nibu Renzhen, Jiefang Yin, Quzhen Gongsang, Huimin Cai, Huasheng Pang, Daxi Wang, Asan, Qingda Zhang, Junhua Li…
    Citation: Parasites & Vectors 2022 15:75
  18. The cuticle protein (CP) encoded by CPR63 plays a role in deltamethrin resistance in Culex pipiens pallens. Herein, we investigated the distribution of CPR63 transcripts in this organism and observed high express...

    Authors: Yang Xu, Jingwei Xu, Yang Zhou, Xixi Li, Yufen Meng, Lei Ma, Dan Zhou, Bo Shen, Yan Sun and Changliang Zhu
    Citation: Parasites & Vectors 2022 15:54
  19. Apicomplexans are important pathogens that cause severe infections in humans and animals. The biology and pathogeneses of these parasites have shown that proteins are intrinsically modulated during development...

    Authors: Joshua Seun Olajide, Zigang Qu, Shunli Yang, Oyeseyi Joshua Oyelade and Jianping Cai
    Citation: Parasites & Vectors 2022 15:38
  20. It is well established that ecdysteroid hormones play an important role in arthropod development and reproduction, mediated by ecdysteroid receptors. Ticks are obligate hematophagous arthropods and vectors of ...

    Authors: Xiaojuan Lu, Zhipeng Zhang, Dongqi Yuan, Yongzhi Zhou, Jie Cao, Houshuang Zhang, Itabajara da Silva Vaz Jr. and Jinlin Zhou
    Citation: Parasites & Vectors 2021 14:612
  21. Cryptosporidium andersoni initiates infection by releasing sporozoites from oocysts through excystation. However, the proteins involved in excystation are unknown. Determining the proteins that participate in the...

    Authors: Dong-Fang Li, Zhao-Hui Cui, Lu-Yang Wang, Kai-Hui Zhang, Le-Tian Cao, Shuang-Jian Zheng and Long-Xian Zhang
    Citation: Parasites & Vectors 2021 14:608
  22. The complex life cycle of Echinococcus granulosus involves numerous environmental conditions within different intermediate and definitive hosts. This requires adaptation at different levels of transcript regulati...

    Authors: Mohammad Ali Mohammadi, Majid Fasihi Harandi, Donald P. McManus and Mehdi Mansouri
    Citation: Parasites & Vectors 2021 14:574
  23. Vaccines against the sexual stages of the malarial parasite Plasmodium falciparum are indispensable for controlling malaria and abrogating the spread of drug-resistant parasites. Pfs25, a surface antigen of the s...

    Authors: Pornpawee Sookpongthai, Korawich Utayopas, Thassanai Sitthiyotha, Theerakamol Pengsakul, Morakot Kaewthamasorn, Kittikhun Wangkanont, Pongchai Harnyuttanakorn, Surasak Chunsrivirot and Sittiporn Pattaradilokrat
    Citation: Parasites & Vectors 2021 14:571
  24. Schistosomiasis is a debilitating and neglected tropical disease for which praziquantel (PZQ) remains the first-choice drug for treatment and control of the disease. In our previous studies, we found that the ...

    Authors: Zi-Yin Yang, Zi-Hao Liu, Ya-Nan Zhang, Chen Li, Lei Liu, Wen-Jie Pu, Shi-Qi Xie, Jing Xu and Chao-Ming Xia
    Citation: Parasites & Vectors 2021 14:550
  25. Schistosomiasis japonica is a serious zoonotic parasitic disease. Preliminary studies have shown that the expression of microRNA-181a (miR-181a) in the liver, lung and spleen tissues of susceptible host BALB/c...

    Authors: Yixiao Tang, Yuanxi Shen, Yang Hong, Zuhang Zhang, Qi Zhai, Zhiqiang Fu, Hao Li, Ke Lu and Jiaojiao Lin
    Citation: Parasites & Vectors 2021 14:548
  26. Chagas disease remains a significant public health problem in Latin America. There are only two chemotherapy drugs, nifurtimox and benznidazole, and both may have severe side effects. After complete chemothera...

    Authors: Niamh Murphy, M. Victoria Cardinal, Tapan Bhattacharyya, Gustavo F. Enriquez, Natalia P. Macchiaverna, Alejandra Alvedro, Héctor Freilij, Pablo Martinez de Salazar, Israel Molina, Pascal Mertens, Quentin Gilleman, Ricardo E. Gürtler and Michael A. Miles
    Citation: Parasites & Vectors 2021 14:543
  27. Malaria control relies mainlyon insecticide-based tools. However, the effectiveness of these tools is threatened by widespread insecticide resistance in malaria vectors, highlighting the need for alternative c...

    Authors: Claudine Grâce Tatsinkou Maffo, Maurice Marcel Sandeu, Amen Nakebang Fadel, Magellan Tchouakui, Daniel Nguiffo Nguete, Benjamin Menze, Michael O. Kusimo, Flobert Njiokou, Grant L. Hughes and Charles S. Wondji
    Citation: Parasites & Vectors 2021 14:539
  28. Alveolar echinococcosis (AE) is a clinically serious zoonosis caused by the fox tapeworm Echinococcus multilocularis. We studied the diversity and the distribution of genotypes of E. multilocularis isolated from...

    Authors: Mandy Herzig, Pavlo Maksimov, Christoph Staubach, Thomas Romig, Jenny Knapp, Bruno Gottstein and Franz J. Conraths
    Citation: Parasites & Vectors 2021 14:535
  29. Abnormal dauer formation gene (daf-5), located downstream of the DAF-7 signalling pathway, mainly functions in dauer formation and reproductive processes in the free-living nematode Caenorhabditis elegans. Althou...

    Authors: Wenda Di, Fangfang Li, Li He, Chunqun Wang, Caixian Zhou, Lu Liu, Lisa Ye, Jian Chen and Min Hu
    Citation: Parasites & Vectors 2021 14:529
  30. The subfamily Phascolostrongylinae (Superfamily Strongyloidea) comprises nematodes that are parasitic in the gastrointestinal tracts of macropodid (Family Macropodidae) and vombatid (Family Vombatidae) marsupi...

    Authors: Tanapan Sukee, Ian Beveridge, Anson V. Koehler, Ross Hall, Robin B. Gasser and Abdul Jabbar
    Citation: Parasites & Vectors 2021 14:523
  31. Eimeria necatrix is one of the most pathogenic parasites, causing high mortality in chickens. Although its genome sequence has been published, the sequences and complete structures of its mRNA transcripts remain ...

    Authors: Yang Gao, Zeyang Suding, Lele Wang, Dandan Liu, Shijie Su, Jinjun Xu, Junjie Hu and Jianping Tao
    Citation: Parasites & Vectors 2021 14:502
  32. Trichinella spiralis (T. spiralis) is a parasite occurring worldwide that has been proven to have antitumour ability. However, studies on the antitumour effects of cross antigens between the tumour and T. spirali...

    Authors: Tao-Tao Yue, Nan Zhang, Jian-Hua Li, Xiang-Yun Lu, Xiao-Cen Wang, Xin Li, Hong-Bo Zhang, Shu-Qin Cheng, Bo-Bo Wang, Peng-Tao Gong and Xi-Chen Zhang
    Citation: Parasites & Vectors 2021 14:498
  33. The tropical bed bug, Cimex hemipterus, is an important ectoparasite causing various health problems. This species is mainly confined to tropical regions; however, insecticide resistance, global warming, and glob...

    Authors: Mohammad Bagher Ghavami, Zarafat Ghahremani, Narges Raeisi and Behrooz Taghiloo
    Citation: Parasites & Vectors 2021 14:470
  34. Babesiosis is a tick-borne disease with global impact caused by parasites of the phylum Apicomplexa, genus Babesia. Typically, acute bovine babesiosis (BB) is characterized by fever, anemia, hemoglobinuria, and h...

    Authors: Lan He, Reginaldo G. Bastos, Yali Sun, Guohua Hua, Guiquan Guan, Junlong Zhao and Carlos E. Suarez
    Citation: Parasites & Vectors 2021 14:460
  35. Head louse females secrete liquid glue during oviposition, which is solidified to form the nit sheath over the egg. Recently, two homologous proteins, named louse nit sheath protein (LNSP) 1 and LNSP 2, were i...

    Authors: Ju Hyeon Kim, Do Eun Lee, SangYoun Park, John M. Clark and Si Hyeock Lee
    Citation: Parasites & Vectors 2021 14:425
  36. Leishmaniasis is a neglected tropical disease caused by several species of Leishmania. The resistance phenotype of these parasites depends on the characteristics of each species, which contributes to increased th...

    Authors: Julián Medina, Lissa Cruz-Saavedra, Luz Helena Patiño, Marina Muñoz and Juan David Ramírez
    Citation: Parasites & Vectors 2021 14:419
  37. Toxoplasmosis caused by Toxoplasma gondii is a serious disease threatening human and animal health. People can be infected with T. gondii by ingesting raw pork contaminated with cysts or oocysts. Serological test...

    Authors: Yongle Song, Yongjuan Zhao, Ke Pan, Bang Shen, Rui Fang, Min Hu, Junlong Zhao and Yanqin Zhou
    Citation: Parasites & Vectors 2021 14:408
  38. Epidemiological surveys in Oman have revealed a high prevalence of the co-occurrence of the pathogenic Theileria lestoquardi and the non-pathogenic Theileria ovis among sheep in the Barka region, Oman. Our most r...

    Authors: Salama Al-Hamidhi, Elshafie I. Elshafie, Saeed Yaghfoori, W. Ivan Morrison, Eugene H. Johnson and Hamza A. Babiker
    Citation: Parasites & Vectors 2021 14:370
  39. Different genotypes of Echinococcus granulosus sensu stricto (s.s.) isolated from livestock and humans have been identified based on cox1 and nad1 genomic fragments. The present study was performed to differentia...

    Authors: Saeed Shahabi, Bahador Sarkari and Afshin Barazesh
    Citation: Parasites & Vectors 2021 14:369
  40. Superoxide dismutase (SOD), a central component of the antioxidant defence system of most organisms, removes excess superoxide anions by converting them to oxygen and hydrogen peroxide. As iron (Fe) SOD is abs...

    Authors: Ana Maria Murta Santi, Paula Alves Silva, Isabella Fernandes Martins Santos and Silvane Maria Fonseca Murta
    Citation: Parasites & Vectors 2021 14:366
  41. Pseudocohnilembus persalinus and Uronema marinum (Ciliophora, Scuticociliatia), as parasitic scuticociliatid ciliates, were isolated from Scophthalmus maximus and Takifugu rubripes, respectively, in our previous ...

    Authors: Yu-Xi Huang, Sen Wang, Yan-Qi Gao, Jie-Hu Chen, Xiu-Li Wang and Rui-Jun Li
    Citation: Parasites & Vectors 2021 14:318
  42. Coccidiosis caused by Eimeria stiedae is a widespread and economically significant disease of rabbits. The lack of studies on the life-cycle development and host interactions of E. stiedae at the molecular level ...

    Authors: Yue Xie, Jie Xiao, Xuan Zhou, Xiaobin Gu, Ran He, Jing Xu, Bo Jing, Xuerong Peng and Guangyou Yang
    Citation: Parasites & Vectors 2021 14:308
  43. Cystic echinococcosis (CE) is a parasitic disease that is caused by Echinococcus granulosus (Eg). The recombinant Echinococcus granulosus antigen P29 (rEg.P29) was shown to confer effective immunity to sheep and ...

    Authors: Chan Wang, Song-Hao Yang, Nan Niu, Jia Tao, Xian-Cai Du, Ji-Hui Yang, Ming-Xing Zhu, Ya-Na Wang and Wei Zhao
    Citation: Parasites & Vectors 2021 14:295
  44. Panstrongylus megistus is the most important vector of Chagas disease in Brazil. Studies show that the principal factor hindering the control of triatomines is reinfestation of houses previously treated with inse...

    Authors: Flávio Campos Ferreira, Leilane Oliveira Gonçalves, Jeronimo Conceição Ruiz, Leonardo Barbosa Koerich, Fabiano Sviatopolk Mirsky Pais, Lileia Gonçalves Diotaiuti and Carlota Josefovicz Belisário
    Citation: Parasites & Vectors 2021 14:273
  45. Fragmented mitochondrial (mt) genomes and extensive mt gene rearrangements have been frequently reported from parasitic lice (Insecta: Phthiraptera). However, relatively little is known about the mt genomes fr...

    Authors: Yu Nie, Yi-Tian Fu, Yu Zhang, Yuan-Ping Deng, Wei Wang, Ya Tu and Guo-Hua Liu
    Citation: Parasites & Vectors 2021 14:269
  46. The predominant genotype of Toxoplasma in China is the Chinese 1 (ToxoDB#9) lineage. TgCtwh3 and TgCtwh6 are two representative strains of Chinese 1, exhibiting high and low virulence to mice, respectively. Littl...

    Authors: Yang Wang, Chengjian Han, Rongsheng zhou, Jinjin Zhu, Famin Zhang, Jingyang Li, Qingli Luo, Jian Du, Deyong Chu, Yihong Cai, Jilong Shen and Li Yu
    Citation: Parasites & Vectors 2021 14:253
  47. Schistosoma japonicum is a parasitic flatworm that is the aetiological agent of human schistosomiasis, an important cause of hepatic fibrosis. Schistosomiasis-induced hepatic fibrosis is a consequence of the high...

    Authors: Jing Huang, Xinguang Yin, Lifang Zhang, Ming Yao, Dahai Wei and Yiming Wu
    Citation: Parasites & Vectors 2021 14:232