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Parasite genetics, genomics and proteomics

Subject Editor
Xing-Quan Zhu, Shanxi Agricultural University, China

Associate Editors
Stephen R. Doyle, Wellcome Sanger Institute, UK
Seth Redmond, Monash University, Australia
Javier Sotillo-Gallego, National Centre for Microbiology, Spain
 

The Parasite genetics, genomics and proteomics section publishes studies applying platform technologies to the innovation of diagnostics, therapeutics and vaccines for parasitic diseases.

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  1. Apicomplexans are important pathogens that cause severe infections in humans and animals. The biology and pathogeneses of these parasites have shown that proteins are intrinsically modulated during development...

    Authors: Joshua Seun Olajide, Zigang Qu, Shunli Yang, Oyeseyi Joshua Oyelade and Jianping Cai

    Citation: Parasites & Vectors 2022 15:38

    Content type: Review

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  2. It is well established that ecdysteroid hormones play an important role in arthropod development and reproduction, mediated by ecdysteroid receptors. Ticks are obligate hematophagous arthropods and vectors of ...

    Authors: Xiaojuan Lu, Zhipeng Zhang, Dongqi Yuan, Yongzhi Zhou, Jie Cao, Houshuang Zhang, Itabajara da Silva Vaz Jr. and Jinlin Zhou

    Citation: Parasites & Vectors 2021 14:612

    Content type: Research

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  3. Cryptosporidium andersoni initiates infection by releasing sporozoites from oocysts through excystation. However, the proteins involved in excystation are unknown. Determining the proteins that participate in the...

    Authors: Dong-Fang Li, Zhao-Hui Cui, Lu-Yang Wang, Kai-Hui Zhang, Le-Tian Cao, Shuang-Jian Zheng and Long-Xian Zhang

    Citation: Parasites & Vectors 2021 14:608

    Content type: Research

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  4. The complex life cycle of Echinococcus granulosus involves numerous environmental conditions within different intermediate and definitive hosts. This requires adaptation at different levels of transcript regulati...

    Authors: Mohammad Ali Mohammadi, Majid Fasihi Harandi, Donald P. McManus and Mehdi Mansouri

    Citation: Parasites & Vectors 2021 14:574

    Content type: Research

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  5. Vaccines against the sexual stages of the malarial parasite Plasmodium falciparum are indispensable for controlling malaria and abrogating the spread of drug-resistant parasites. Pfs25, a surface antigen of the s...

    Authors: Pornpawee Sookpongthai, Korawich Utayopas, Thassanai Sitthiyotha, Theerakamol Pengsakul, Morakot Kaewthamasorn, Kittikhun Wangkanont, Pongchai Harnyuttanakorn, Surasak Chunsrivirot and Sittiporn Pattaradilokrat

    Citation: Parasites & Vectors 2021 14:571

    Content type: Research

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  6. Schistosomiasis is a debilitating and neglected tropical disease for which praziquantel (PZQ) remains the first-choice drug for treatment and control of the disease. In our previous studies, we found that the ...

    Authors: Zi-Yin Yang, Zi-Hao Liu, Ya-Nan Zhang, Chen Li, Lei Liu, Wen-Jie Pu, Shi-Qi Xie, Jing Xu and Chao-Ming Xia

    Citation: Parasites & Vectors 2021 14:550

    Content type: Research

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  7. Schistosomiasis japonica is a serious zoonotic parasitic disease. Preliminary studies have shown that the expression of microRNA-181a (miR-181a) in the liver, lung and spleen tissues of susceptible host BALB/c...

    Authors: Yixiao Tang, Yuanxi Shen, Yang Hong, Zuhang Zhang, Qi Zhai, Zhiqiang Fu, Hao Li, Ke Lu and Jiaojiao Lin

    Citation: Parasites & Vectors 2021 14:548

    Content type: Research

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  8. Chagas disease remains a significant public health problem in Latin America. There are only two chemotherapy drugs, nifurtimox and benznidazole, and both may have severe side effects. After complete chemothera...

    Authors: Niamh Murphy, M. Victoria Cardinal, Tapan Bhattacharyya, Gustavo F. Enriquez, Natalia P. Macchiaverna, Alejandra Alvedro, Héctor Freilij, Pablo Martinez de Salazar, Israel Molina, Pascal Mertens, Quentin Gilleman, Ricardo E. Gürtler and Michael A. Miles

    Citation: Parasites & Vectors 2021 14:543

    Content type: Research

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  9. Malaria control relies mainlyon insecticide-based tools. However, the effectiveness of these tools is threatened by widespread insecticide resistance in malaria vectors, highlighting the need for alternative c...

    Authors: Claudine Grâce Tatsinkou Maffo, Maurice Marcel Sandeu, Amen Nakebang Fadel, Magellan Tchouakui, Daniel Nguiffo Nguete, Benjamin Menze, Michael O. Kusimo, Flobert Njiokou, Grant L. Hughes and Charles S. Wondji

    Citation: Parasites & Vectors 2021 14:539

    Content type: Research

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  10. Alveolar echinococcosis (AE) is a clinically serious zoonosis caused by the fox tapeworm Echinococcus multilocularis. We studied the diversity and the distribution of genotypes of E. multilocularis isolated from...

    Authors: Mandy Herzig, Pavlo Maksimov, Christoph Staubach, Thomas Romig, Jenny Knapp, Bruno Gottstein and Franz J. Conraths

    Citation: Parasites & Vectors 2021 14:535

    Content type: Research

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  11. Abnormal dauer formation gene (daf-5), located downstream of the DAF-7 signalling pathway, mainly functions in dauer formation and reproductive processes in the free-living nematode Caenorhabditis elegans. Althou...

    Authors: Wenda Di, Fangfang Li, Li He, Chunqun Wang, Caixian Zhou, Lu Liu, Lisa Ye, Jian Chen and Min Hu

    Citation: Parasites & Vectors 2021 14:529

    Content type: Research

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  12. The subfamily Phascolostrongylinae (Superfamily Strongyloidea) comprises nematodes that are parasitic in the gastrointestinal tracts of macropodid (Family Macropodidae) and vombatid (Family Vombatidae) marsupi...

    Authors: Tanapan Sukee, Ian Beveridge, Anson V. Koehler, Ross Hall, Robin B. Gasser and Abdul Jabbar

    Citation: Parasites & Vectors 2021 14:523

    Content type: Research

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  13. Eimeria necatrix is one of the most pathogenic parasites, causing high mortality in chickens. Although its genome sequence has been published, the sequences and complete structures of its mRNA transcripts remain ...

    Authors: Yang Gao, Zeyang Suding, Lele Wang, Dandan Liu, Shijie Su, Jinjun Xu, Junjie Hu and Jianping Tao

    Citation: Parasites & Vectors 2021 14:502

    Content type: Research

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  14. Trichinella spiralis (T. spiralis) is a parasite occurring worldwide that has been proven to have antitumour ability. However, studies on the antitumour effects of cross antigens between the tumour and T. spirali...

    Authors: Tao-Tao Yue, Nan Zhang, Jian-Hua Li, Xiang-Yun Lu, Xiao-Cen Wang, Xin Li, Hong-Bo Zhang, Shu-Qin Cheng, Bo-Bo Wang, Peng-Tao Gong and Xi-Chen Zhang

    Citation: Parasites & Vectors 2021 14:498

    Content type: Research

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  15. The tropical bed bug, Cimex hemipterus, is an important ectoparasite causing various health problems. This species is mainly confined to tropical regions; however, insecticide resistance, global warming, and glob...

    Authors: Mohammad Bagher Ghavami, Zarafat Ghahremani, Narges Raeisi and Behrooz Taghiloo

    Citation: Parasites & Vectors 2021 14:470

    Content type: Research

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  16. Babesiosis is a tick-borne disease with global impact caused by parasites of the phylum Apicomplexa, genus Babesia. Typically, acute bovine babesiosis (BB) is characterized by fever, anemia, hemoglobinuria, and h...

    Authors: Lan He, Reginaldo G. Bastos, Yali Sun, Guohua Hua, Guiquan Guan, Junlong Zhao and Carlos E. Suarez

    Citation: Parasites & Vectors 2021 14:460

    Content type: Review

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  17. Head louse females secrete liquid glue during oviposition, which is solidified to form the nit sheath over the egg. Recently, two homologous proteins, named louse nit sheath protein (LNSP) 1 and LNSP 2, were i...

    Authors: Ju Hyeon Kim, Do Eun Lee, SangYoun Park, John M. Clark and Si Hyeock Lee

    Citation: Parasites & Vectors 2021 14:425

    Content type: Research

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  18. Leishmaniasis is a neglected tropical disease caused by several species of Leishmania. The resistance phenotype of these parasites depends on the characteristics of each species, which contributes to increased th...

    Authors: Julián Medina, Lissa Cruz-Saavedra, Luz Helena Patiño, Marina Muñoz and Juan David Ramírez

    Citation: Parasites & Vectors 2021 14:419

    Content type: Research

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  19. Toxoplasmosis caused by Toxoplasma gondii is a serious disease threatening human and animal health. People can be infected with T. gondii by ingesting raw pork contaminated with cysts or oocysts. Serological test...

    Authors: Yongle Song, Yongjuan Zhao, Ke Pan, Bang Shen, Rui Fang, Min Hu, Junlong Zhao and Yanqin Zhou

    Citation: Parasites & Vectors 2021 14:408

    Content type: Research

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  20. Epidemiological surveys in Oman have revealed a high prevalence of the co-occurrence of the pathogenic Theileria lestoquardi and the non-pathogenic Theileria ovis among sheep in the Barka region, Oman. Our most r...

    Authors: Salama Al-Hamidhi, Elshafie I. Elshafie, Saeed Yaghfoori, W. Ivan Morrison, Eugene H. Johnson and Hamza A. Babiker

    Citation: Parasites & Vectors 2021 14:370

    Content type: Research

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  21. Different genotypes of Echinococcus granulosus sensu stricto (s.s.) isolated from livestock and humans have been identified based on cox1 and nad1 genomic fragments. The present study was performed to differentia...

    Authors: Saeed Shahabi, Bahador Sarkari and Afshin Barazesh

    Citation: Parasites & Vectors 2021 14:369

    Content type: Short report

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  22. Superoxide dismutase (SOD), a central component of the antioxidant defence system of most organisms, removes excess superoxide anions by converting them to oxygen and hydrogen peroxide. As iron (Fe) SOD is abs...

    Authors: Ana Maria Murta Santi, Paula Alves Silva, Isabella Fernandes Martins Santos and Silvane Maria Fonseca Murta

    Citation: Parasites & Vectors 2021 14:366

    Content type: Short report

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  23. Pseudocohnilembus persalinus and Uronema marinum (Ciliophora, Scuticociliatia), as parasitic scuticociliatid ciliates, were isolated from Scophthalmus maximus and Takifugu rubripes, respectively, in our previous ...

    Authors: Yu-Xi Huang, Sen Wang, Yan-Qi Gao, Jie-Hu Chen, Xiu-Li Wang and Rui-Jun Li

    Citation: Parasites & Vectors 2021 14:318

    Content type: Research

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  24. Coccidiosis caused by Eimeria stiedae is a widespread and economically significant disease of rabbits. The lack of studies on the life-cycle development and host interactions of E. stiedae at the molecular level ...

    Authors: Yue Xie, Jie Xiao, Xuan Zhou, Xiaobin Gu, Ran He, Jing Xu, Bo Jing, Xuerong Peng and Guangyou Yang

    Citation: Parasites & Vectors 2021 14:308

    Content type: Research

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  25. Cystic echinococcosis (CE) is a parasitic disease that is caused by Echinococcus granulosus (Eg). The recombinant Echinococcus granulosus antigen P29 (rEg.P29) was shown to confer effective immunity to sheep and ...

    Authors: Chan Wang, Song-Hao Yang, Nan Niu, Jia Tao, Xian-Cai Du, Ji-Hui Yang, Ming-Xing Zhu, Ya-Na Wang and Wei Zhao

    Citation: Parasites & Vectors 2021 14:295

    Content type: Research

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  26. Panstrongylus megistus is the most important vector of Chagas disease in Brazil. Studies show that the principal factor hindering the control of triatomines is reinfestation of houses previously treated with inse...

    Authors: Flávio Campos Ferreira, Leilane Oliveira Gonçalves, Jeronimo Conceição Ruiz, Leonardo Barbosa Koerich, Fabiano Sviatopolk Mirsky Pais, Lileia Gonçalves Diotaiuti and Carlota Josefovicz Belisário

    Citation: Parasites & Vectors 2021 14:273

    Content type: Short report

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  27. Fragmented mitochondrial (mt) genomes and extensive mt gene rearrangements have been frequently reported from parasitic lice (Insecta: Phthiraptera). However, relatively little is known about the mt genomes fr...

    Authors: Yu Nie, Yi-Tian Fu, Yu Zhang, Yuan-Ping Deng, Wei Wang, Ya Tu and Guo-Hua Liu

    Citation: Parasites & Vectors 2021 14:269

    Content type: Research

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  28. The predominant genotype of Toxoplasma in China is the Chinese 1 (ToxoDB#9) lineage. TgCtwh3 and TgCtwh6 are two representative strains of Chinese 1, exhibiting high and low virulence to mice, respectively. Littl...

    Authors: Yang Wang, Chengjian Han, Rongsheng zhou, Jinjin Zhu, Famin Zhang, Jingyang Li, Qingli Luo, Jian Du, Deyong Chu, Yihong Cai, Jilong Shen and Li Yu

    Citation: Parasites & Vectors 2021 14:253

    Content type: Research

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  29. Schistosoma japonicum is a parasitic flatworm that is the aetiological agent of human schistosomiasis, an important cause of hepatic fibrosis. Schistosomiasis-induced hepatic fibrosis is a consequence of the high...

    Authors: Jing Huang, Xinguang Yin, Lifang Zhang, Ming Yao, Dahai Wei and Yiming Wu

    Citation: Parasites & Vectors 2021 14:232

    Content type: Research

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  30. The mitochondrial (mt) genomes of Sarcoptiformes mites typically contain 37 genes. Although the loss of genes is rare in Sarcoptiformes mite mitogenomes, two of the six previously reported oribatid mites (Acar...

    Authors: Xue-Bing Zhan, Bing Chen, Yu Fang, Fang-Yuan Dong, Wei-Xi Fang, Qian Luo, Ling-Miao Chu, Rui Feng, Yan Wang, Xuan Su, Ying Fang, Jiao-Yang Xu, Ze-Tao Zuo, Xing-Quan Xia, Jie-Gen Yu and En-Tao Sun

    Citation: Parasites & Vectors 2021 14:221

    Content type: Research

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  31. Biliary tract infection with the carcinogenic human liver fluke, Clonorchis sinensis, provokes chronic inflammation, epithelial hyperplasia, periductal fibrosis, and even cholangiocarcinoma. Complications are pro...

    Authors: Jung-Woong Kim, Junyeong Yi, Jinhong Park, Ji Hoon Jeong, Jinho Kim, Jihee Won, Seok Chung, Tong-Soo Kim and Jhang Ho Pak

    Citation: Parasites & Vectors 2021 14:213

    Content type: Research

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  32. Nematodes of the family Cosmocercidae (Ascaridomorpha: Cosmocercoidea) are mainly parasitic in the digestive tract of various amphibians and reptiles worldwide. However, our knowledge of the molecular phylogen...

    Authors: Hui-Xia Chen, Xiao-Hong Gu, Xue-Feng Ni and Liang Li

    Citation: Parasites & Vectors 2021 14:165

    Content type: Research

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  33. Entamoeba species harbored by humans have different degrees of pathogenicity. The present study explores the intra- and interspecific diversity, phylogenetic relationships, prevalence and distribution of tetra- a...

    Authors: Deiviane Aparecida Calegar, Kerla Joeline Lima Monteiro, Polyanna Araújo Alves Bacelar, Brenda Bulsara Costa Evangelista, Mayron Morais Almeida, Jéssica Pereira dos Santos, Márcio Neves Boia, Beatriz Coronato-Nunes, Lauren Hubert Jaeger and Filipe Anibal Carvalho-Costa

    Citation: Parasites & Vectors 2021 14:160

    Content type: Research

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  34. The NF-κB signalling pathway has been reported to be related to liver fibrosis, and we investigated whether the NF-κB signalling pathway is involved in liver fibrosis caused by secreted phospholipase A2 of Clonor...

    Authors: Yin-Juan Wu, Qing He, Mei Shang, Ying-Xuan Yin, Ye Li, Xue Du and Xue-Rong Li

    Citation: Parasites & Vectors 2021 14:152

    Content type: Research

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  35. Parasites of the genus Trichinella are the pathogenic agents of trichinellosis, which is a widespread and severe foodborne parasitic disease. Trichinella spiralis resides primarily in mammalian skeletal muscle ce...

    Authors: Xiaoxiang Hu, Xiaolei Liu, Chen Li, Yulu Zhang, Chengyao Li, Yanfeng Li, Yingxi Chen, Heng Guo, Xue Bai and Mingyuan Liu

    Citation: Parasites & Vectors 2021 14:130

    Content type: Research

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  36. Excretory-secretory (ES) products are crucial in maintaining helminths in the host. Consequently, the proteins of ES are potential vaccine molecules and potential therapeutic agents for autoimmune diseases. Helig...

    Authors: Marta Maruszewska-Cheruiyot, Ludmiła Szewczak, Katarzyna Krawczak-Wójcik, Magdalena Głaczyńska and Katarzyna Donskow-Łysoniewska

    Citation: Parasites & Vectors 2021 14:106

    Content type: Research

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  37. Cystic echinococcosis is a parasitic zoonotic disease, which poses a threat to public health and animal husbandry, and causes significant economic losses. Annexins are a family of phospholipid-binding proteins...

    Authors: Hongyu Song, Xue He, Xiaodi Du, Ruiqi Hua, Jing Xu, Ran He, Yue Xie, Xiaobin Gu, Xuerong Peng and Guangyou Yang

    Citation: Parasites & Vectors 2021 14:103

    Content type: Research

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  38. Culicoides imicola (Diptera: Ceratopogonidae) is an important Afrotropical and Palearctic vector of disease, transmitting viruses of animal health and economic significance including African horse sickness and bl...

    Authors: Jack Pilgrim, Stefanos Siozios, Matthew Baylis, Gert Venter, Claire Garros and Gregory D. D. Hurst

    Citation: Parasites & Vectors 2021 14:100

    Content type: Short report

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    The Correction to this article has been published in Parasites & Vectors 2021 14:128

  39. Small non-coding RNAs play critical regulatory roles in post-transcription. However, their characteristics in Trichomonas vaginalis, the causative agent of human sexually transmitted trichomoniasis, still remain ...

    Authors: Zhen-Sheng Wang, Hong-Chang Zhou, Chun-Yan Wei, Zhi-Hua Wang, Xiao Hao, Lian-Hui Zhang, Jing-Zhong Li, Zeng-Lei Wang and Heng Wang

    Citation: Parasites & Vectors 2021 14:87

    Content type: Research

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  40. Cryptosporidiosis is a gastrointestinal disease with global distribution. It has been a reportable disease in Canada since 2000; however, routine molecular surveillance is not conducted. Therefore, sources of ...

    Authors: Rebecca A. Guy, Christine A. Yanta, Pia K. Muchaal, Marisa A. Rankin, Karine Thivierge, Rachel Lau and Andrea K. Boggild

    Citation: Parasites & Vectors 2021 14:69

    Content type: Research

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  41. Babesia is a protozoan parasite that infects red blood cells in some vertebrates. Some species of Babesia can induce zoonoses and cause considerable harm. As the largest immune organ in mammals, the spleen plays...

    Authors: Xiaomin Xue, Shuguang Ren, Xiaohong Yang, Abolfazl Masoudi, Yuhong Hu, Xiaoshuang Wang, Hongxia Li, Xiaojing Zhang, Minjing Wang, Hui Wang and Jingze Liu

    Citation: Parasites & Vectors 2021 14:61

    Content type: Research

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  42. The avian haematophagous ectoparasite Dermanyssus gallinae, commonly known as the poultry red mite, causes significant economic losses to the egg-laying industry worldwide and also represents a significant welfar...

    Authors: Wan Chen, Kathryn Bartley, Francesca Nunn, Alan S. Bowman, Jeremy M. Sternberg, Stewart T. G. Burgess, Alasdair J. Nisbet and Daniel R. G. Price

    Citation: Parasites & Vectors 2021 14:57

    Content type: Research

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  43. Blastocystis sp. is an anaerobic protozoan that parasitizes many animal hosts and the human gastrointestinal tract, and its pathogenicity is controversial. Captive wildlife may be potential reservoirs for human i...

    Authors: Lei Deng, Jingxin Yao, Shanyu Chen, Tingmei He, Yijun Chai, Ziyao Zhou, Xiaogang Shi, Haifeng Liu, Zhijun Zhong, Hualin Fu and Guangneng Peng

    Citation: Parasites & Vectors 2021 14:11

    Content type: Research

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  44. Parasitic infections can increase susceptibility to bacterial co-infections. This may be true for urogenital schistosomiasis and bacterial urinary tract co-infections (UTI). We previously reported that this co...

    Authors: Evaristus C. Mbanefo, Loc Le, Luke F. Pennington, Yi- Ju Hsieh, Justin I. Odegaard, Kristina Lapira, Theodore S. Jardetzky, Franco H. Falcone and Michael H. Hsieh

    Citation: Parasites & Vectors 2020 13:615

    Content type: Research

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  45. Current measures for the prevention of dirofilariasis, caused by the dog heartworm, Dirofilaria immitis, rely on macrocyclic lactones, but evidence of drug-resistant isolates has called for alternative approaches...

    Authors: Tsai-Chi Shang Kuan and Roger K. Prichard

    Citation: Parasites & Vectors 2020 13:614

    Content type: Research

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